MOTS-c is a short peptide encoded within mitochondrial DNA rather than the nuclear genome, which makes it unusual among signalling peptides. It is supplied here for in-vitro laboratory research use only.
MOTS-c (mitochondrial open reading frame of the twelve S rRNA type-c) is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA region. It was first characterised in 2015, in work published in Cell Metabolism identifying it as a mitochondrial-derived peptide with metabolic signalling activity.
Its significance in the research literature comes from the idea that mitochondria do not only produce energy but also encode peptides that signal to the rest of the cell and to the nucleus. MOTS-c is one of the most studied examples of that concept.
Most of the work is preclinical — cell culture and rodent models. There are human association studies examining circulating MOTS-c levels in relation to metabolic measures, but these are observational and do not establish that administering the peptide produces any effect.
MOTS-c is encoded in mitochondrial DNA, translated, and has been observed to act beyond the mitochondrion itself. Research examines how such peptides communicate mitochondrial state to the wider cell.
Preclinical work has examined MOTS-c in relation to the folate-methionine cycle and AMPK signalling, pathways involved in cellular energy sensing. These are the pathways most often cited in the literature.
Work has reported MOTS-c moving to the nucleus under metabolic stress conditions and associating with stress-responsive transcriptional activity. This remains an active area of investigation rather than a settled mechanism.
Batch documentation for MOTS-C is available on request where we hold it. We do not publish a public batch database, and no purity, identity, sterility or manufacturing claim is stated anywhere on this site unless documentation for that exact batch supports it. To ask what is held for a particular lot, contact us.
These are starting points for your own reading, not endorsements of any conclusion.
It is encoded in mitochondrial DNA rather than in the nuclear genome. Most signalling peptides are nuclear-encoded, so mitochondrial-derived peptides represent a distinct category.
There are human association studies looking at circulating MOTS-c levels alongside metabolic measures. These are observational. No interventional trial has established an effect from administering the peptide.
Principally AMPK signalling and the folate-methionine cycle, both involved in cellular energy sensing. These are areas of active investigation, not settled conclusions.
Lyophilised peptide is generally held sealed and frozen, protected from light. Specific storage conditions for the batch you receive are stated on its documentation.
This product is supplied strictly for in-vitro laboratory research. It is not a medicine, is not licensed by the MHRA, and is not for human or veterinary consumption or administration. We do not supply dosing, reconstitution or administration guidance, and nothing on this page is a therapeutic claim.